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KMID : 0043320010240010027
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Archives of Pharmacal Research
2001 Volume.24 No. 1 p.27 ~ p.34
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Synthesis and Preliminary Antimicrobial Screening of New Benzimidazole Heterocycles
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:H.H. Fahmy
:A. El-masry/:S.H. Ali Abdelwahed
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Abstract
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A series of 2-methylbenzimidazole incorporated to different heterocycles through ethyl or carbamoyiethyl groups at position 1 of benzimidazole were synthesized. Also 3-(2- methy lbenzimidazol-1-yl)propanoic acid hydrazide incorporated with semicarbazides and thiosemicar bazides were prepared. Moreover, the triazole 5e underwent Michael addition and alkylation reaction. Some of the newly synthesized compounds showed considerable antimicrobial activity against gram positive, negative bacteria and yeast.
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KEYWORD
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